cholesterol biosynthesis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1576	Diallyl disulfide		IL Receptor , NOS , NF-κB
	Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.		IL Receptor , NOS , NF-κB
T14362	AY 9944		Others
	AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomera...		Others
TN6715	7-Ketocholesterol		Others
	7-Ketocholesterol is a metabolite of Cholesterol		Others
T26296	Triparanol	MER-29,NSC 65345,NSC-65345,NSC65345	Apoptosis , Hedgehog/Smoothened
	Triparanol (NSC-65345) interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparan...		Apoptosis , Hedgehog/Smoothened
T35973	Cholesterol-5α,6α-epoxide	Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE applicat...		Others
T19711	Desmosterol	Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite
	Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.		Endogenous Metabolite
T12092	Monacolin J	Antibiotic MB 530A,Lovastatin diol lactone	HMG-CoA Reductase , Autophagy
	Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.		HMG-CoA Reductase , Autophagy
T4923	7-Dehydrocholesterol	Provitamin D3,7-DHC	Endogenous Metabolite
	7-Dehydrocholesterol (Provitamin D3) down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.		Endogenous Metabolite
T25285	Dalvastatin	RG-12561,RG 12561,RG12561	HMG-CoA Reductase
	Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvast...		HMG-CoA Reductase
T4717	25-Hydroxycholesterol		Others , Endogenous Metabolite , HMG-CoA Reductase
	25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regu...		Others , Endogenous Metabolite , HMG-CoA Reductase
T41054	γ-Glutamyl-S-allylcysteine	L-γ-Glutamyl-(S)-Allyl-Cysteine	Antioxidant
	γ-Glutamyl-S-allylcysteine (L-γ-Glutamyl-(S)-Allyl-Cysteine) is a γ-glutamyl peptide extracted from Allium sativum L. γ-Glutamyl-S-allylcysteine possesses anti-glycation and antioxidant activities, and can inhibit the ch...		Antioxidant
T1664	Meglutol	Dicrotalic acid,3-Hydroxy-3-methylglutaric acid	Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Meglutol (3-Hydroxy-3-methylglutaric acid) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conve...		Endogenous Metabolite , HMG-CoA Reductase , Autophagy
T15184	E 2012		Gamma-secretase
	E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc...		Gamma-secretase
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T4039	BIBB 515		Others
	BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of...		Others
T15710	Lapaquistat	T-91485	Others
	Lapaquistat is a cholesterol biosynthesis inhibitor and is the active metabolite of TAK-475. Lapaquistat can reduce statin-induced myotoxicity in lipid-lowering therapy.		Others
T20999	1-(2,3-Dichlorphenyl)-piperazine	DCPP	Others
	1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.		Others
T28142	NCX-6560	NCX6560
	NCX-6560 is a novel NO-releasing derivative of atorvastatin, with those of atorvastatin. NCX-6560 inhibits cholesterol biosynthesis in rat smooth muscle cells with an IC50 of 1.9 μM.
T73808	Zymosterol
	Zymosterol, a metabolite in cholesterol biosynthesis and precursor to cholesterol, predominantly resides in the plasma membrane and circulates within the cell [1] [2].
T38088	28-Deoxybetulin methyleneamine
	28-Deoxybetulin methyleneamine is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It has been used in the synthesis of triterpene derivatives with antiviral activity. 1.Nitz,...